Harness the Microbiome to Stimulate Hormone Production in the Gut

Study Rationale:

Hormones encompass a wide array of biological molecules, ranging from neurohormones to sex hormones. Emerging research has demonstrated potential links between hormones and the gut microbiome. Specifically, it has been demonstrated that sex hormones [MGN1] both influence and are influenced by the gut microbiota (Baker, Al-Nakkash, and Herbst-Kralovetz, 2017). Emerging studies on the estrobolome, which is composed of gut microorganisms responsible for converting estrogen to its bioactive form, have suggested that gut microorganisms may play an important role in regulating estrogen levels.

Study Impact and Next Steps:

Elucidating the role of endogenous microorganisms in producing and regulating estrogen production is a new avenue that requires further inquiry. With increases in the aging population, women of post-menopausal age represent a burgeoning demographic [MGN2] susceptible to health-related issues due to significant decreases in estrogen levels. Such decreases are associated with increased risk of cardiovascular events, memory loss, decreases in bone density, and other health issues (Baker, Al-Nakkash, and Herbst-Kralovetz, 2017). Thus, the development of therapies that harness the human microbiome could present an attractive option for maintaining estrogen levels in this segment of the population.

We invite you to join in the search to elucidate the mechanisms of microbial production and regulation of sex hormones and to investigate potential microbiome therapies for women of post-menopausal age.